Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215818 | 0.73 | CA2 (0.39) | RECQLCA1CA2CA12CA7 | |
| SCHEMBL670938 | 0.72 | PNMT (0.45) | — | |
| SCHEMBL1462095 | 0.68 | CA2 (0.37) | RECQLCA1CA2CA9PTGES2 | |
| SCHEMBL4767876 | 0.67 | TAAR1 (0.58) | RECQLCA1PTGES2 | |
| SCHEMBL4881315 | 0.66 | TAAR1 (0.57) | RECQLCA1CA2 | |
| SCHEMBL27833064 | 0.65 | TSHR (0.49) | CA1CA2CA9CA12CA7 | |
| SCHEMBL14784589 | 0.64 | CA1 (0.43) | CA1CA2CA9CA12CA7 | |
| SCHEMBL1492042 | 0.63 | CA1 (0.34) | CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL5534744 | 0.63 | RECQL (0.40) | RECQLCA2PTGES2 | |
| SCHEMBL17648977 | 0.63 | TSHR (0.39) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470538-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025940-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |