Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462095 | 0.84 | CA2 (0.37) | CA2RECQLCA1 | |
| SCHEMBL1494448 | 0.73 | MGLL (0.37) | CA2RECQLMGLLCA12CA1 | |
| SCHEMBL1492045 | 0.73 | RECQL (0.40) | CA2RECQLCA12CA1CA7 | |
| SCHEMBL1462230 | 0.71 | CA2 (0.30) | CA2 | |
| SCHEMBL671337 | 0.68 | LOXL2 (0.39) | — | |
| SCHEMBL29467988 | 0.68 | LOXL2 (0.39) | — | |
| SCHEMBL25437680 | 0.65 | MGLL (0.62) | CA2MGLLCA12CA1 | |
| SCHEMBL15924708 | 0.65 | TAAR1 (0.53) | CA2MGLLCA12CA1 | |
| SCHEMBL28452491 | 0.64 | APLNR (0.49) | CA2CA12CA1CA7 | |
| SCHEMBL16058359 | 0.63 | CA2 (0.45) | CA2CA12CA1CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470511-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025965-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-03-03 | — | — | WO | disclosed |