Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL6315070 | 1.00 | MAPT (0.62) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL3532294 | 0.87 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3532296 | 0.87 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL14926720 | 0.85 | MAPT (0.50) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL1745374 | 0.85 | BACE1 (0.69) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL31155851 | 0.85 | MAPT (0.58) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL672165 | 0.84 | MAPT (0.49) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL3179934 | 0.84 | ABL1 (0.51) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL8267197 | 0.84 | MAPT (0.49) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL3173933 | 0.84 | MAPT (0.49) | MAPTALDH1A1KDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234798-A | Sulfamate derivative compounds for the treatment or alleviation of psychotic disorders | 生物药品解决方案有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-106507667-B | Sulfamate derivatives for the prevention or treatment of epilepsy | 比皮艾思药物研发有限公司 | 2020-01-24 | — | — | CN | disclosed |
| EP-2935249-B1 | AUTOTAXIN INHIBITORS | NOVARTIS AG (CH) | 2018-12-12 | — | — | EP | disclosed |
| US-9630945-B2 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2017-04-25 | — | — | US | disclosed |
| US-20170007614-A1 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2017-01-12 | — | — | US | disclosed |
| US-9409895-B2 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2016-08-09 | — | — | US | disclosed |
| US-20150307475-A1 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2015-10-29 | — | — | US | disclosed |
| EP-2935249-A2 | AUTOTAXIN INHIBITORS | Novartis AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| EP-2861571-A1 | PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME | Bio-Pharm Solutions Co., Ltd. (KR) | 2015-04-22 | — | — | EP | disclosed |
| WO-2014097151-A2 | AUTOTAXIN INHIBITORS | NOVARTIS AG (CH) | 2014-06-26 | — | — | WO | disclosed |
| US-20140171404-A1 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2014-06-19 | — | — | US | disclosed |
| US-20140171403-A1 | Autotaxin inhibitors | NOVARTIS AG (CH) | 2014-06-19 | — | — | US | disclosed |
| WO-2013187727-A1 | PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME | BIO-PHARM SOLUTIONS CO., LTD. (KR) | 2013-12-19 | — | — | WO | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |
| EP-0526535-B1 | CYCLIC HYDROXAMIC ACIDS AND THEIR USE | ORION YHTYMAE OY (FI) | 1995-09-27 | — | — | EP | disclosed |
| US-5356923-A | 1-hydroxy-4(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone and anti-hypertensive use thereof | ORION-YHTYMA OY (FI) | 1994-10-18 | — | — | US | disclosed |
| EP-0526535-A1 | CYCLIC HYDROXAMIC ACIDS AND THEIR USE. | ORION YHTYMAE OY (FI) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991016303-A1 | CYCLIC HYDROXAMIC ACIDS AND THEIR USE | Orion-Yhtymä Oy (FI) | 1991-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307475-A1 | Autotaxin inhibitors | ENPP2, ATXN10, ATXN2L | MAPT 259/4885ALDH1A1 3712/4885KDM4E 3188/4885 |
| US-20140171403-A1 | Autotaxin inhibitors | ENPP2, SERPINB1, TFPI | MAPT 249/4885ALDH1A1 4843/4885KDM4E 4073/4885 |
| US-20140171404-A1 | Autotaxin inhibitors | ENPP2, ATXN10, ATXN2L | MAPT 160/4885ALDH1A1 4601/4885KDM4E 2714/4885 |
| US-20170007614-A1 | Autotaxin inhibitors | ENPP2, SERPINB1, TFPI | MAPT 249/4885ALDH1A1 4843/4885KDM4E 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.