Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 3/20 | 0.52 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492896 | 0.92 | WNT3A (0.52) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492661 | 0.89 | WNT3A (0.57) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492739 | 0.88 | ROCK2 (0.53) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1782313 | 0.84 | NPC1 (0.69) | WNT3APORCNPSEN1PSEN2APH1B | |
| SCHEMBL1492890 | 0.84 | WNT3A (0.47) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1493021 | 0.83 | CNR1 (0.60) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492651 | 0.83 | PSEN1 (0.69) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492799 | 0.82 | PRMT3 (0.59) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492885 | 0.82 | PORCN (0.71) | WNT3APORCNROCK2ROCK1PSEN1 | |
| SCHEMBL1492676 | 0.81 | CNR1 (0.58) | WNT3APORCNROCK2ROCK1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |