Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 6/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.46 |
| ▸ | FPR2 | P25090 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492756 | 0.86 | FPR2 (0.61) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492673 | 0.84 | WNT3A (0.52) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492960 | 0.83 | CNR1 (0.66) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492661 | 0.83 | WNT3A (0.57) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492739 | 0.82 | ROCK2 (0.53) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492799 | 0.82 | PRMT3 (0.59) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492949 | 0.81 | WNT3A (0.50) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1493021 | 0.80 | CNR1 (0.60) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL7967030 | 0.79 | ROCK2 (0.52) | WNT3AROCK2PSEN1PSEN2APH1B | |
| SCHEMBL1492889 | 0.79 | ROCK2 (0.52) | WNT3AROCK2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |