Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.60 |
| ▸ | RB1 | P06400 | 6/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088610 | 0.95 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL14584257 | 0.88 | BRD3 (0.57) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL11827085 | 0.83 | DRD2 (0.54) | BRD3CHRNA7ADRA1DADRA1AADRA1B | |
| SCHEMBL16258989 | 0.81 | BRD3 (0.60) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL13733389 | 0.80 | BRD3 (0.56) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL13751061 | 0.80 | BRD3 (0.56) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL13748402 | 0.80 | RB1 (0.68) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL11383479 | 0.79 | BRD3 (0.52) | BRD3RB1SIRT1SIRT2CHRNA7 | |
| SCHEMBL16521421 | 0.79 | SIRT1 (0.63) | SIRT1SIRT2MEN1KMT2A | |
| SCHEMBL7074767 | 0.77 | HTR7 (0.55) | BRD3CHRNA7ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116283-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | BRD3 671/4885RB1 1973/4885SIRT1 872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.