Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940346 | 0.94 | SIGMAR1 (0.44) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939880 | 0.90 | NPSR1 (0.52) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939744 | 0.89 | LMNA (0.45) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939485 | 0.89 | SIGMAR1 (0.51) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939836 | 0.86 | TACR1 (0.45) | DRD2CHRM3TACR1 | |
| SCHEMBL14940059 | 0.85 | NPSR1 (0.49) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14940496 | 0.84 | ACHE (0.52) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939526 | 0.84 | NPSR1 (0.46) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939854 | 0.84 | CHRM2 (0.43) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL14939469 | 0.83 | SIGMAR1 (0.50) | SIGMAR1DRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |