Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939099 | 0.88 | KMT2A (0.43) | HTR6ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL14940496 | 0.88 | ACHE (0.52) | HTR6ACHELMNADRD2SIGMAR1 | |
| SCHEMBL14938846 | 0.87 | ALDH1A1 (0.41) | HTR6ACHEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14939483 | 0.86 | ALDH1A1 (0.45) | HTR6ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL14939941 | 0.85 | KMT2A (0.47) | ACHEKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL14939708 | 0.83 | KMT2A (0.42) | HTR6ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL14939065 | 0.82 | MAPT (0.54) | CYP26A1CYP24A1ACHEKDM4EALDH1A1 | |
| SCHEMBL14940048 | 0.81 | ALDH1A1 (0.44) | ACHEKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL14939485 | 0.81 | SIGMAR1 (0.51) | HTR6ACHEALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14939092 | 0.80 | KDM4E (0.49) | ACHEKDM4EALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |