Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | TXN | P10599 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940191 | 0.85 | RAPGEF4 (0.54) | NFKB1RAPGEF4CRHR1 | |
| SCHEMBL11639629 | 0.81 | NFKB1 (0.47) | NFKB1TSHRMAPTMEN1MAPK1 | |
| SCHEMBL14940545 | 0.81 | RAPGEF4 (0.54) | NFKB1RAPGEF4APPNPC1POLB | |
| SCHEMBL14939921 | 0.79 | CYP2C9 (0.47) | NFKB1RAPGEF4MAPTMEN1MAPK1 | |
| SCHEMBL1181589 | 0.78 | NFKB1 (0.53) | NFKB1TSHRMAPTMEN1MAPK1 | |
| SCHEMBL15266054 | 0.78 | TXN (0.42) | NFKB1TSHRMAPTMEN1MAPK1 | |
| SCHEMBL11652163 | 0.77 | MAPT (0.47) | NFKB1TSHRMAPTMEN1MAPK1 | |
| SCHEMBL14939965 | 0.77 | NFKB1 (0.56) | NFKB1HTR1DTSHRMAPTMEN1 | |
| SCHEMBL3827194 | 0.69 | MAPT (0.40) | HTR1DHTR1BMAPTMEN1MAPK1 | |
| SCHEMBL11638656 | 0.68 | TSHR (0.47) | NFKB1RAPGEF4TSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2828244-B1 | TRIAZINES WITH SUITABLE SPACERS FOR TREATMENT AND/OR PREVENTION OF HIV INFECTIONS | UNIV ANTWERPEN (BE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2828244-B1 | TRIAZINES WITH SUITABLE SPACERS FOR TREATMENT AND/OR PREVENTION OF HIV INFECTIONS | UNIV ANTWERPEN (BE) | 2017-11-15 | — | — | EP | disclosed |
| US-9650348-B2 | Triazines with suitable spacers for treatment and/or prevention of HIV infections | UNIVERSITEIT ANTWERPEN (BE) | 2017-05-16 | — | — | US | disclosed |
| US-9650348-B2 | Triazines with suitable spacers for treatment and/or prevention of HIV infections | UNIVERSITEIT ANTWERPEN (BE) | 2017-05-16 | — | — | US | disclosed |
| US-9650348-B2 | Triazines with suitable spacers for treatment and/or prevention of HIV infections | UNIVERSITEIT ANTWERPEN (BE) | 2017-05-16 | — | — | US | disclosed |
| US-20150126510-A1 | Triazines With Suitable Spacers for Treatment And/Or Prevention of HIV Infections | UNIVERSITEIT ANTWERPEN (BE) | 2015-05-07 | — | — | US | disclosed |
| US-20150126510-A1 | Triazines With Suitable Spacers for Treatment And/Or Prevention of HIV Infections | UNIVERSITEIT ANTWERPEN (BE) | 2015-05-07 | — | — | US | disclosed |
| US-20150126510-A1 | Triazines With Suitable Spacers for Treatment And/Or Prevention of HIV Infections | UNIVERSITEIT ANTWERPEN (BE) | 2015-05-07 | — | — | US | disclosed |
| EP-2828244-A1 | TRIAZINES WITH SUITABLE SPACERS FOR TREATMENT AND/OR PREVENTION OF HIV INFECTIONS | Universiteit Antwerpen (BE) | 2015-01-28 | — | — | EP | disclosed |
| US-20140323488-A1 | DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES | UNIVERSITEIT ANTWERPEN (BE) | 2014-10-30 | — | — | US | disclosed |
| US-20140323488-A1 | DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES | UNIVERSITEIT ANTWERPEN (BE) | 2014-10-30 | — | — | US | disclosed |
| EP-2776410-A1 | DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES | Universiteit Antwerpen (BE) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013139727-A1 | TRIAZINES WITH SUITABLE SPACERS FOR TREATMENT AND/OR PREVENTION OF HIV INFECTIONS | UNIVERSITEIT ANTWERPEN (BE) | 2013-09-26 | — | — | WO | disclosed |
| WO-2013139727-A1 | TRIAZINES WITH SUITABLE SPACERS FOR TREATMENT AND/OR PREVENTION OF HIV INFECTIONS | UNIVERSITEIT ANTWERPEN (BE) | 2013-09-26 | — | — | WO | disclosed |
| WO-2013068551-A1 | DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES | UNIVERSITEIT ANTWERPEN (BE) | 2013-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323488-A1 | DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES | TBC1D15, TBC1D5, DHFR | NFKB1 559/4885HTR1D 4223/4885HTR1B 3768/4885 |
| US-20150126510-A1 | Triazines With Suitable Spacers for Treatment And/Or Prevention of HIV Infections | IKZF2, IKZF3, BAZ2A | NFKB1 2319/4885HTR1D 3073/4885HTR1B 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.