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Sugi Predict / Compounds / SCHEMBL14949261

SCHEMBL14949261

SCHEMBL14949261

Cc1cccc(Nc2nnc(-c3ccc(Oc4cc(OCC5CC5)nc(N)n4)cc3)[nH]2)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 3/20 0.34
▸ RAB9A P51151 3/20 0.34
▸ NOD1 Q9Y239 1/20 0.34
▸ PDGFRB P09619 1/20 0.33
▸ KIT P10721 1/20 0.33
▸ PDGFRA P16234 1/20 0.33
▸ CDK11B P21127 1/20 0.33
▸ FLT3 P36888 1/20 0.33
▸ CDKL2 Q92772 1/20 0.33
▸ MAPT P10636 4/20 0.33
▸ TP53 P04637 2/20 0.33
▸ CCNA2 P20248 4/20 0.33
▸ CDK2 P24941 4/20 0.33
▸ USP2 O75604 2/20 0.33
▸ CDK1 P06493 1/20 0.33
▸ CCNB1 P14635 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ FFAR1 O14842 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949247 0.89 RAB9A (0.37) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL12336260 0.88 PDGFRB (0.45) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL14949260 0.86 KIT (0.37) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL14949279 0.86 PDGFRB (0.37) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL14949288 0.83 RAB9A (0.39) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL14949256 0.82 ROCK1 (0.39) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL14949331 0.81 RAB9A (0.39) NPC1RAB9ANOD1MAPTTP53
SCHEMBL16786019 0.80 NUDT1 (0.37) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL14949254 0.80 RAB9A (0.38) NPC1RAB9AMAPTTP53MEN1
SCHEMBL14949297 0.79 PDGFRB (0.37) NPC1RAB9ANOD1PDGFRBKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.