Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22732655 | 0.90 | ALDH1A1 (0.43) | KMT2AALDH1A1KDM4EMEN1L3MBTL1 | |
| SCHEMBL22732628 | 0.90 | ALDH1A1 (0.43) | KMT2AALDH1A1KDM4EMEN1L3MBTL1 | |
| SCHEMBL14949559 | 0.90 | ALDH1A1 (0.43) | KMT2AALDH1A1KDM4EMEN1L3MBTL1 | |
| SCHEMBL3400613 | 0.90 | NCF1 (0.44) | KMT2ANCF1ALDH1A1CYP2C9SLC9A1 | |
| SCHEMBL24456533 | 0.85 | DPP8 (0.41) | KMT2ATACR3ALDH1A1RBP4KDM4E | |
| SCHEMBL14949543 | 0.82 | TACR3 (0.41) | NCF1TACR3 | |
| SCHEMBL24449428 | 0.82 | RBP4 (0.41) | KMT2ATACR3ALDH1A1RBP4KDM4E | |
| SCHEMBL12506994 | 0.81 | CHRNB2 (0.43) | NCF1TACR3ALDH1A1 | |
| SCHEMBL10272741 | 0.81 | CHRNB2 (0.43) | NCF1TACR3ALDH1A1 | |
| SCHEMBL3425809 | 0.79 | GNAI3 (0.41) | KMT2AALDH1A1KDM4EMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |