Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 3/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xanthine SCHEMBL4965 | 0.79 | GDA (1.00) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL29669592 | 0.79 | GDA (1.00) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL2352524 | 0.79 | GDA (1.00) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL31152020 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL7044227 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL31048830 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL1507586 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL31488667 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL2454001 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 | |
| Xanthine SCHEMBL6783299 | 0.78 | GDA (0.96) | GDAACHEADORA2BTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952016-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| EP-2473052-A1 | SUBSTITUTED XANTHINE DERIVATIVES | Concert Pharmaceuticals Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| US-20110059995-A1 | SUBSTITUTED XANTHINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2011-03-10 | — | — | US | disclosed |
| WO-2011028835-A1 | SUBSTITUTED XANTHINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059995-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, HPRT1, CXCR3 | GDA 334/4885ACHE 945/4885ADORA2B 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.