SCHEMBL149581

SCHEMBL149581

COC(=O)C=Cc1ccccc1F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.59
MAPT P10636 5/20 0.52
RAB9A P51151 3/20 0.52
NPC1 O15118 2/20 0.52
NFE2L2 Q16236 3/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
ALDH1A1 P00352 3/20 0.50
KDM4E B2RXH2 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2D6 P10635 1/20 0.50
CYP1B1 Q16678 1/20 0.50
TP53 P04637 1/20 0.50
CYP2C9 P11712 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
CYP2C19 P33261 1/20 0.50
HSD17B10 Q99714 1/20 0.50
MMP1 P03956 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL149579 1.00 MAOB (0.59) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL29900779 1.00 MAOB (0.59) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL10438847 0.87 ALDH1A1 (0.58) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL69522 0.87 ALDH1A1 (0.58) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL14930494 0.86 PTGS2 (0.54) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL11061667 0.85 ALDH1A1 (0.56) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL27647189 0.83 KDM4E (0.46) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL2149382 0.83 KDM4E (0.46) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL30578183 0.83 KDM4E (0.46) MAOBMAPTRAB9ANPC1NFE2L2
SCHEMBL30814249 0.83 MAOB (0.56) MAOBMAPTRAB9ANPC1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115927221-B Method for synthesizing methyl epoxycinnamate compound by biocatalysis 湖南师范大学 2024-12-31 CN claimed
CN-115927221-B Method for synthesizing methyl epoxycinnamate compound by biocatalysis 湖南师范大学 2024-12-31 CN disclosed
CN-115927221-A Method for synthesizing epoxy methyl cinnamate compounds through biocatalysis 湖南师范大学 2023-04-07 CN disclosed
CN-115927221-A Method for synthesizing epoxy methyl cinnamate compounds through biocatalysis 湖南师范大学 2023-04-07 CN disclosed
EP-3617183-B1 PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS DAIKIN IND LTD (JP) 2022-09-28 EP disclosed
EP-3617183-A1 PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS DAIKIN INDUSTRIES, LTD. (JP) 2020-03-04 EP disclosed
US-9950984-B2 Production method for alpha-fluoro acrylic acid esters DAIKIN INDUSTRIES, LTD. (JP) 2018-04-24 US disclosed
US-20170267626-A1 PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS DAIKIN INDUSTRIES, LTD. (JP) 2017-09-21 US disclosed
US-9732027-B2 Production method for alpha-fluoro acrylic acid esters DAIKIN INDUSTRIES, LTD. (JP) 2017-08-15 US disclosed
US-9701614-B2 2017-07-11 US disclosed
US-6407115-B1 ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION, WATER SOLUBILITY DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-06-18 US disclosed
US-5834476-A DERIVATIVE OF CAMPTOTHECIN, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1998-11-10 US disclosed
US-5770605-A Method for treating leukemia with a hexa-cyclic compound DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1998-06-23 US disclosed
US-5658920-A ANTITUMOR AGENTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-08-19 US disclosed
US-5637770-A Hexa-cyclic compound DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-06-10 US disclosed
EP-0495432-B1 Hexa-cyclic compound DAIICHI SEIYAKU CO (JP) 1996-05-29 EP disclosed
EP-0495432-A1 Hexa-cyclic compound DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1992-07-22 EP disclosed
US-4237306-A ELECTROPHILIC REACTIONS WITH ALKYL ARYL KETONES TO PRODUCE METHYL ARYL ALKANOATES EMERY INDUSTRIES, INC. (US) 1980-12-02 US disclosed
US-4172955-A REARRANGMENT OF A CINNAMALDEHYDE TO A PHENYLMALONDIALDEHYDE TETRAMETHYL DISACETAL EMERY INDUSTRIES, INC. (US) 1979-10-30 US disclosed
US-4067823-A Thallium(III) reagents supported on montmorillonite clay minerals and oxythallation processes for utilizing same EMERY INDUSTRIES, INC. (US) 1978-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170267626-A1 PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS ADH1A, AFF1, ADH5 MAOB 1163/4885MAPT 4643/4885RAB9A 2094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.