Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12160901 | 0.82 | MEN1 (0.50) | GAAMAPTHSD11B1HSD17B1ALDH1A1 | |
| SCHEMBL12160727 | 0.82 | MEN1 (0.50) | GAAMAPTHSD11B1HSD17B1ALDH1A1 | |
| SCHEMBL12160730 | 0.79 | L3MBTL1 (0.47) | GAAMAPTHSD11B1HSD17B1ALDH1A1 | |
| SCHEMBL12160900 | 0.79 | L3MBTL1 (0.47) | GAAMAPTHSD11B1HSD17B1ALDH1A1 | |
| SCHEMBL31722815 | 0.76 | ALDH1A1 (0.60) | GAAALDH1A1MAPK1CYP2C9CYP2C19 | |
| SCHEMBL24725070 | 0.76 | NPC1 (0.48) | GAAMAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL26899136 | 0.74 | NPC1 (0.46) | GAAMAPTHSD11B1HSD17B1ALDH1A1 | |
| SCHEMBL26878431 | 0.74 | LMNA (0.48) | MAPTHSD11B1HSD17B1ALDH1A1MEN1 | |
| SCHEMBL25083897 | 0.74 | LMNA (0.48) | MAPTHSD11B1HSD17B1ALDH1A1MEN1 | |
| SCHEMBL486204 | 0.71 | MAPT (0.49) | DPP4GAAMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445515-B2 | C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2013-05-21 | — | — | US | disclosed |