SCHEMBL1496249

SCHEMBL1496249

COc1ccccc1[PH](=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.46
CA2 P00918 4/20 0.46
CA7 P43166 3/20 0.46
CA9 Q16790 3/20 0.46
CA12 O43570 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CA4 P22748 1/20 0.46
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
HTR6 P50406 1/20 0.39
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
TP53 P04637 1/20 0.39
TSHR P16473 1/20 0.39
ADRA2B P18089 1/20 0.39
PTGS1 P23219 1/20 0.39
KMT2A Q03164 3/20 0.38
HTT P42858 2/20 0.38
MAPK1 P28482 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30679175 1.00 CA1 (0.46) CA1CA2CA7CA9CA12
Lithium SCHEMBL30679176 0.98 CA1 (0.44) CA1CA2CA7CA9CA12
Hydrochloric Acid SCHEMBL29393964 0.98 CA1 (0.44) CA1CA2CA7CA9CA12
SCHEMBL2153848 0.87 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL25798207 0.87 CA1 (0.41) CA1CA2CA7CA9CA12
SCHEMBL29067572 0.83 HTT (0.32) KMT2AHTTLMNA
SCHEMBL25798209 0.83 NFE2L2 (0.42) CA1CA2CA7CA9CA12
SCHEMBL13240564 0.80 CA12 (0.46) CA1CA2CA7CA9CA12
SCHEMBL2155675 0.79 ALDH1A1 (0.33) ALDH1A1TDP1TSHR
SCHEMBL2153988 0.79 IRAK4 (0.42) CA1CA2CA7CA9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230212204-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS THE SCRIPPS RESEARCH INSTITUTE 2023-07-06 US disclosed
EP-3184171-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-20 EP disclosed
EP-2858750-B1 PHOSPHINYL GUANIDINE COMPOUNDS, CHROMIUM SALT COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2019-03-13 EP disclosed
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-12-04 US disclosed
US-9962689-B2 Phosphinyl formamidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2018-05-08 US disclosed
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP 2017-10-26 US disclosed
US-9732106-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2017-08-15 US disclosed
EP-3184171-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS Chevron Phillips Chemical Company LP (US) 2017-06-28 EP disclosed
EP-2475716-B1 HYDROXYPHENYL PHOSPHINE OXIDE MIXTURES AND THEIR USE AS FLAME RETARDANTS FOR EPOXY RESINS CHEMTURA CORP (US) 2017-04-19 EP disclosed
EP-2519532-B1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-03-08 EP disclosed
WO-2011031834-A1 HYDROXYPHENYL PHOSPHINE OXIDE MIXTURES AND THEIR USE AS FLAME RETARDANTS FOR EPOXY RESINS CHEMTURA CORPORATION (US) 2011-03-17 WO disclosed
US-20110065869-A1 Hydroxyphenyl phosphine oxide mixtures and their use as flame retardant's for epoxy resins LANXESS SOLUTIONS US INC. 2011-03-17 US disclosed
EP-1866087-B1 CATALYTIC TRIMERIZATION AND TETRAMERIZATION OF OLEFINIC MONOMERS SHELL INT RESEARCH (NL) 2009-08-26 EP disclosed
US-7381857-B2 Catalytic trimerization and tetramerization of olefinic monomers SHELL OIL COMPANY (US) 2008-06-03 US disclosed
US-20070299290-A1 CATALYTIC TRIMERIZATION AND TETRAMERIZATION OF OLEFINIC MONOMERS DE BOER ERIC J M 2007-12-27 US disclosed
US-7273959-B2 Catalytic trimerization of olefinic monomers SHELL OIL COMPANY (US) 2007-09-25 US disclosed
US-7259123-B2 Catalytic trimerization and tetramerization of olefinic monomers SHELL OIL COMPANY (US) 2007-08-21 US disclosed
US-20060235250-A1 Catalytic trimerization and tetramerization of olefinic monomers SHELL OIL COMPANY 2006-10-19 US disclosed
US-20050113622-A1 Catalytic trimerization of olefinic monomers SHELL OIL COMPANY 2005-05-26 US disclosed
US-6214196-B1 ELECTROLYSIS COUPLING OF PHOSPHINE OXIDE CARBOXYLIC ACID NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2001-04-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10144752-B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins NIT2, NCLN, NPM1 CA1 676/4885CA2 475/4885CA7 1701/4885
US-20110065869-A1 Hydroxyphenyl phosphine oxide mixtures and their use as flame retardant's for epoxy resins PFAS, PHOSPHO1, PTGER4 CA1 3352/4885CA2 3738/4885CA7 3693/4885
US-20230212204-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS PNKP, POLL, RNGTT CA1 2759/4885CA2 3521/4885CA7 1778/4885
US-20170305945-A1 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins NIT2, NCLN, NPM1 CA1 676/4885CA2 475/4885CA7 1701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.