Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964194 | 0.89 | SMN1; SMN2 (0.37) | IDO1SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL14964279 | 0.87 | IDO1 (0.33) | IDO1 | |
| SCHEMBL4980217 | 0.85 | TAAR1 (0.35) | IDO1SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4979731 | 0.85 | IDO1 (0.34) | IDO1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL16581960 | 0.84 | HTR1A (0.36) | SIGMAR1HTR1AIDO1SMN1; SMN2KMT2A | |
| SCHEMBL14461786 | 0.84 | SMN1; SMN2 (0.43) | SIGMAR1HTR1ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14964214 | 0.82 | ALDH1A1 (0.33) | SIGMAR1IDO1SMN1; SMN2KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL15093526 | 0.81 | IDO1 (0.32) | IDO1SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4984827 | 0.81 | CA2 (0.44) | IDO1SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL14462353 | 0.81 | SMN1; SMN2 (0.44) | HTR1ASMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |