Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979731 | 0.86 | IDO1 (0.34) | MEN1MAPTKMT2ALMNAIDO1 | |
| SCHEMBL4984827 | 0.86 | CA2 (0.44) | MEN1MAPTKMT2ALMNAKDM4E | |
| SCHEMBL14964340 | 0.85 | SIGMAR1 (0.36) | MEN1KMT2ALMNAKDM4EGAA | |
| SCHEMBL14964214 | 0.84 | ALDH1A1 (0.33) | MEN1KMT2ALMNAKDM4EGAA | |
| SCHEMBL14964279 | 0.83 | IDO1 (0.33) | IDO1TDO2 | |
| SCHEMBL14462336 | 0.83 | MEN1 (0.45) | TAAR1MEN1MAPTKMT2ALMNA | |
| SCHEMBL14964194 | 0.83 | SMN1; SMN2 (0.37) | MEN1KMT2ALMNAKDM4ENPC1 | |
| SCHEMBL14964273 | 0.81 | ALOX15 (0.40) | MEN1MAPTKMT2ALMNACYP1A2 | |
| Trifluoroacetic Acid SCHEMBL15093526 | 0.81 | IDO1 (0.32) | MEN1MAPTKMT2ALMNACYP1A2 | |
| SCHEMBL15093527 | 0.80 | MAPT (0.32) | MEN1MAPTKMT2AIDO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971583-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007075598-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |