Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964260 | 0.95 | EGFR (0.39) | FYNEGFRALDH1A1GAAEPHX2 | |
| SCHEMBL16581822 | 0.86 | EGFR (0.38) | FYNEGFRALDH1A1GAAEPHX2 | |
| SCHEMBL14964261 | 0.86 | CYP2A13 (0.37) | FYNEGFRALDH1A1LMNAKMT2A | |
| SCHEMBL4979731 | 0.84 | IDO1 (0.34) | ALDH1A1HTTLMNAKMT2AIDO1 | |
| SCHEMBL14461931 | 0.84 | EGFR (0.47) | FYNEGFRALDH1A1GAAEPHX2 | |
| SCHEMBL15092999 | 0.84 | EGFR (0.35) | FYNEGFRLMNAKMT2AIDO1 | |
| SCHEMBL4979807 | 0.84 | ALDH1A1 (0.34) | ALDH1A1GAALMNAKMT2AIDO1 | |
| SCHEMBL14964214 | 0.82 | ALDH1A1 (0.33) | EGFRALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL14964279 | 0.81 | IDO1 (0.33) | IDO1 | |
| SCHEMBL14964179 | 0.81 | HPGD (0.36) | EGFRKMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |