Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14462764 | 0.85 | LMNA (0.42) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL14964215 | 0.84 | FYN (0.40) | ALDH1A1GAALMNAKMT2AIDO1 | |
| SCHEMBL15092999 | 0.83 | EGFR (0.35) | POLQLMNAKMT2APIK3CDPIK3CB | |
| SCHEMBL14964260 | 0.82 | EGFR (0.39) | ALDH1A1GAALMNAL3MBTL1CYP3A4 | |
| SCHEMBL5630763 | 0.81 | LMNA (0.42) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL5630752 | 0.81 | LMNA (0.42) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL14964261 | 0.80 | CYP2A13 (0.37) | ALDH1A1LMNAKMT2ANPC1RAB9A | |
| SCHEMBL5630766 | 0.78 | IDO1 (0.52) | IDO1 | |
| SCHEMBL4979731 | 0.78 | IDO1 (0.34) | ALDH1A1LMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL14964214 | 0.78 | ALDH1A1 (0.33) | ALDH1A1GAALMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971583-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007075598-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |