Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964215 | 0.95 | FYN (0.40) | EGFRALDH1A1EPHX2FYNSMN1; SMN2 | |
| SCHEMBL16581822 | 0.89 | EGFR (0.38) | EGFRALDH1A1L3MBTL1EPHX2FYN | |
| SCHEMBL14964261 | 0.85 | CYP2A13 (0.37) | EGFRALDH1A1FYNLMNA | |
| SCHEMBL14462338 | 0.84 | EGFR (0.47) | EGFRCYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL14964279 | 0.83 | IDO1 (0.33) | — | |
| SCHEMBL4979731 | 0.83 | IDO1 (0.34) | ALDH1A1L3MBTL1LMNA | |
| SCHEMBL14964273 | 0.82 | ALOX15 (0.40) | CYP2C19CYP3A4CYP2D6ALDH1A1L3MBTL1 | |
| SCHEMBL15092999 | 0.82 | EGFR (0.35) | EGFRCYP3A4FYNLMNA | |
| SCHEMBL4979807 | 0.82 | ALDH1A1 (0.34) | CYP3A4ALDH1A1L3MBTL1GAALMNA | |
| SCHEMBL5631314 | 0.80 | EGFR (0.46) | EGFRCYP2C19CYP3A4CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |