Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599013 | 0.90 | KMT2A (0.53) | POLBHTTKMT2A | |
| SCHEMBL27978752 | 0.85 | RAB9A (0.58) | HTTKMT2ARAB9A | |
| SCHEMBL17599008 | 0.84 | KMT2A (0.77) | POLBHTTKMT2A | |
| SCHEMBL14965405 | 0.83 | — | — | |
| SCHEMBL27978708 | 0.80 | KMT2A (0.49) | KMT2ARAB9A | |
| SCHEMBL17599014 | 0.80 | MEN1 (0.49) | HTTKMT2ARAB9A | |
| SCHEMBL14964774 | 0.75 | POLB (0.66) | POLBHTTKMT2A | |
| SCHEMBL14965036 | 0.75 | LMNA (0.67) | POLBHTTKMT2A | |
| SCHEMBL14965055 | 0.74 | POLB (0.65) | POLBHTTKMT2A | |
| SCHEMBL16292937 | 0.74 | POLB (0.80) | POLBHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| CN-104011054-A | Thieno- and furo-pyrimidines and pyridines, useful as potassium channel inhibitors | XENTION LTD | 2014-08-27 | — | — | CN | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |