Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965999 | 0.87 | ALDH1A1 (0.43) | SMN1; SMN2KDM4EALDH1A1MAPK1NPSR1 | |
| SCHEMBL14965773 | 0.87 | L3MBTL1 (0.46) | SMN1; SMN2TDP1KDM4EALDH1A1POLB | |
| SCHEMBL14971091 | 0.87 | DRD2 (0.44) | SMN1; SMN2KDM4EALDH1A1MAPK1POLB | |
| SCHEMBL14965821 | 0.86 | ALDH1A1 (0.33) | SMN1; SMN2KDM4EALDH1A1MAPK1NPSR1 | |
| SCHEMBL14965968 | 0.85 | LMNA (0.48) | KDM4EALDH1A1MAPK1NPSR1FAAH | |
| SCHEMBL14965629 | 0.85 | L3MBTL1 (0.36) | SMN1; SMN2KDM4EALDH1A1MAPK1NPSR1 | |
| SCHEMBL14966205 | 0.84 | LSS (0.46) | TDP1KDM4EALDH1A1POLB | |
| SCHEMBL14966131 | 0.84 | DRD2 (0.49) | SMN1; SMN2TDP1KDM4EALDH1A1MEN1 | |
| SCHEMBL14966240 | 0.83 | KIT (0.40) | POLB | |
| SCHEMBL14966118 | 0.83 | ALDH1A1 (0.39) | SMN1; SMN2TDP1KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |