Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.51 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462430 | 0.87 | P2RX7 (0.56) | ALPLP2RX7NPC1RAB9AMAPT | |
| SCHEMBL4469262 | 0.84 | ALPL (0.51) | ALPLP2RX7CYP4F2CYP4A11NPC1 | |
| SCHEMBL4260262 | 0.83 | CYP4F2 (0.52) | ALPLCYP4F2CYP4A11NPC1RAB9A | |
| SCHEMBL4471895 | 0.82 | P2RX7 (0.57) | ALPLP2RX7NPC1RAB9AMAPT | |
| SCHEMBL3346686 | 0.82 | P2RX7 (0.57) | ALPLP2RX7NPC1RAB9AL3MBTL1 | |
| SCHEMBL14966653 | 0.81 | P2RX7 (0.64) | ALPLP2RX7NPC1RAB9AMAPT | |
| SCHEMBL5267093 | 0.80 | ALPL (0.59) | ALPLNPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL5271085 | 0.77 | MAPT (0.55) | ALPLNPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL4255413 | 0.77 | JMJD6 (0.55) | ALPLP2RX7CYP4F2CYP4A11NPC1 | |
| SCHEMBL4503741 | 0.76 | CYP4F2 (0.60) | CYP4F2CYP4A11PTGDRALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |