Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.45 |
| ▸ | FEN1 | P39748 | 4/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471895 | 0.88 | P2RX7 (0.57) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3342192 | 0.87 | ALPL (0.49) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14966653 | 0.86 | P2RX7 (0.64) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4462430 | 0.85 | P2RX7 (0.56) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL14965792 | 0.82 | ALPL (0.56) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3346696 | 0.78 | NPC1 (0.53) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL3345938 | 0.75 | KDM4E (0.44) | P2RX7NPC1L3MBTL1ALOX5ALOX5AP | |
| SCHEMBL4469098 | 0.75 | P2RX7 (0.52) | P2RX7NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5799212 | 0.74 | P2RX7 (0.59) | P2RX7NPC1RAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL4460890 | 0.73 | P2RX7 (0.58) | P2RX7ALOX5ALOX5APFEN1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | P2RX7 8/4885NPC1 1906/4885RAB9A 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.