Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 11/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965987 | 0.84 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14966321 | 0.84 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14966068 | 0.81 | NPBWR1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14966623 | 0.81 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14966025 | 0.77 | MEN1 (0.44) | POLBLMNAMEN1KMT2ACA12 | |
| SCHEMBL5324211 | 0.77 | SMN1; SMN2 (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14966296 | 0.76 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28766387 | 0.76 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14965963 | 0.75 | L3MBTL1 (0.50) | ALDH1A1LMNAMEN1KMT2AKAT2B | |
| SCHEMBL14966484 | 0.74 | KEAP1 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |