Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965582 | 0.86 | HSD17B10 (0.38) | KMT2ATDP1ALDH1A1MEN1LMNA | |
| SCHEMBL14965417 | 0.84 | NAMPT (0.43) | KMT2ATDP1ALDH1A1KDM4ELMNA | |
| SCHEMBL14965791 | 0.82 | KDM4E (0.36) | PKMKMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL14966123 | 0.82 | KMT2A (0.52) | KMT2ATDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL14969489 | 0.82 | ALDH1A1 (0.43) | TDP1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL14965808 | 0.81 | LMNA (0.47) | KMT2ATDP1ALDH1A1MEN1LMNA | |
| SCHEMBL14966002 | 0.81 | HPGD (0.54) | PKMKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL14965869 | 0.81 | ALDH1A1 (0.41) | PKMKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL14966113 | 0.81 | POLB (0.39) | PKMKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL14966168 | 0.80 | ALDH1A1 (0.40) | KMT2AALDH1A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |