SCHEMBL14966009

SCHEMBL14966009

CS(=O)(=O)c1cc(F)c(CN2CCN(C3CCN(C#N)CC3)C2=O)cc1F

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 4/20 0.34
LMNA P02545 2/20 0.32
PER2 O15055 6/20 0.32
RXFP1 Q9HBX9 1/20 0.31
TP53 P04637 1/20 0.31
BTK Q06187 1/20 0.30
CTSK P43235 1/20 0.30
CTSC P53634 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14978693 0.84 TP53 (0.41) LMNAPER2RXFP1TP53
SCHEMBL14978024 0.82 TP53 (0.35) PER2TP53BTK
SCHEMBL14978756 0.80 PER2 (0.37) LMNAPER2TP53
SCHEMBL14966666 0.79 GPR119 (0.49) TP53
SCHEMBL14966714 0.78 GPR119 (0.35) LMNA
Trifluoroacetic Acid SCHEMBL14966444 0.77 TP53 (0.36) PER2TP53
SCHEMBL16163126 0.77 HRH3 (0.37)
SCHEMBL14970194 0.76 GPR119 (0.48) TP53
SCHEMBL14966286 0.76 CXCR3 (0.42)
SCHEMBL14968863 0.75 HDAC1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140309226-A1 PIPERIDINYL-SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS ARRAY BIOPHARMA, INC. 2014-10-16 US disclosed
WO-2013074641-A1 PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2013-05-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140309226-A1 PIPERIDINYL-SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS GPR119, UTS2R, GPR139 USP30 423/4885LMNA 3409/4885PER2 1189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.