Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967310 | 0.85 | CYP4A11 (0.49) | CYP4F2CYP4A11MAPTALDH1A1PKM | |
| SCHEMBL14967550 | 0.81 | POLB (0.55) | CYP4F2CYP4A11POLBNR4A2ALDH1A1 | |
| SCHEMBL14966872 | 0.80 | LTA4H (0.56) | CYP4F2CYP4A11TBXAS1NAPRTPOLB | |
| SCHEMBL14967498 | 0.78 | ELOVL1 (0.40) | LTA4HPIM1PIM2 | |
| SCHEMBL14967192 | 0.75 | POLB (0.51) | CYP4F2CYP4A11TBXAS1POLBNR4A2 | |
| SCHEMBL6769826 | 0.73 | NAPRT (0.64) | TBXAS1NAPRTPOLBRARBALDH1A1 | |
| SCHEMBL4255608 | 0.73 | MAPT (0.59) | NR4A2MAPTGCK | |
| Hydrochloric Acid SCHEMBL3896488 | 0.72 | NAPRT (0.61) | TBXAS1NAPRTPOLBRARBALDH1A1 | |
| SCHEMBL11891840 | 0.72 | SRD5A2 (0.54) | NAPRTPOLB | |
| SCHEMBL5390756 | 0.71 | PKM (0.73) | NR4A2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |