Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405035 | 0.86 | PLA2G4B (0.58) | LTA4HCYP4F2CYP4A11PKMTBXAS1 | |
| SCHEMBL5390756 | 0.85 | PKM (0.73) | PKMNR4A2FFAR1PLA2G4BMEN1 | |
| SCHEMBL14966638 | 0.83 | MAPT (0.61) | LTA4HCYP4F2CYP4A11MEN1LMNA | |
| SCHEMBL14967365 | 0.82 | NR4A2 (0.73) | CYP4F2CYP4A11PKMNR4A2FFAR1 | |
| SCHEMBL4327125 | 0.81 | PKM (0.73) | PKMNR4A2FFAR1PLA2G4BMEN1 | |
| SCHEMBL9042414 | 0.81 | LTA4H (0.57) | LTA4HFFAR1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6769826 | 0.81 | NAPRT (0.64) | TBXAS1NAPRTMEN1KMT2ATP53 | |
| SCHEMBL4374627 | 0.81 | NR4A2 (0.71) | PKMNR4A2FFAR1PLA2G4BMAPK1 | |
| SCHEMBL14967104 | 0.81 | PKM (0.57) | PKMNR4A2FFAR1PLA2G4BMAPK1 | |
| SCHEMBL14966199 | 0.80 | CYP4F2 (0.45) | LTA4HCYP4F2CYP4A11PKMTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |