Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965729 | 0.88 | KCNH2 (0.42) | KCNH2CACNA1CSCN5ACHRM1PTGS1 | |
| SCHEMBL14965833 | 0.83 | KCNH2 (0.41) | KCNH2CACNA1CSCN5ACHRM1PTGS1 | |
| SCHEMBL14965407 | 0.81 | KCNJ1 (0.42) | CHRM1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL14965368 | 0.79 | KCNJ1 (0.40) | ALDH1A1KMT2AMEN1LMNAKCNJ1 | |
| SCHEMBL14965776 | 0.76 | KCNH2 (0.42) | KCNH2CACNA1CSCN5ACHRM1PTGS1 | |
| SCHEMBL14965626 | 0.73 | LTA4H (0.40) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL14965511 | 0.73 | LTA4H (0.40) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL14965560 | 0.72 | HIF1A (0.40) | KCNH2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL14965638 | 0.71 | KCNH2 (0.40) | KCNH2CACNA1CSCN5ACHRM1PTGS1 | |
| SCHEMBL5543339 | 0.71 | PTGS1 (0.49) | KCNH2CACNA1CSCN5APTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |