Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966961 | 0.86 | LMNA (0.49) | RAB9AMAPTLMNAKMT2AMEN1 | |
| SCHEMBL14967047 | 0.86 | ALDH1A1 (0.50) | RAB9AMAPTNPC1LMNASMN1; SMN2 | |
| SCHEMBL14966314 | 0.80 | KMT2A (0.53) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL14966465 | 0.80 | KMT2A (0.52) | RAB9AMAPTNPC1LMNASMN1; SMN2 | |
| SCHEMBL15669422 | 0.77 | NPC1 (0.53) | RAB9AMAPTNPC1LMNASMN1; SMN2 | |
| SCHEMBL2586590 | 0.77 | KCNQ3 (0.54) | RAB9AMAPTNPC1LMNAKMT2A | |
| SCHEMBL14967228 | 0.76 | TSHR (0.47) | RAB9AMAPTLMNAL3MBTL1KDM4E | |
| SCHEMBL14967136 | 0.76 | L3MBTL1 (0.55) | RAB9AMAPTNPC1LMNAKMT2A | |
| SCHEMBL9038245 | 0.74 | ADRA2A (0.48) | RAB9AMAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL31475537 | 0.74 | HTT (0.50) | RAB9AMAPTLMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |