Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967136 | 0.83 | L3MBTL1 (0.55) | TSHRLMNARAB9AL3MBTL1MAPT | |
| SCHEMBL14967228 | 0.83 | TSHR (0.47) | SLC6A3TSHRLMNARAB9AL3MBTL1 | |
| SCHEMBL14967047 | 0.82 | ALDH1A1 (0.50) | TSHRLMNASMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL17319608 | 0.78 | SMN1; SMN2 (0.46) | ADRA2AADRA2BTSHRLMNASMN1; SMN2 | |
| SCHEMBL14972056 | 0.78 | TSHR (0.56) | TSHRSMN1; SMN2RAB9AL3MBTL1MAPT | |
| SCHEMBL14966893 | 0.78 | TSHR (0.56) | TSHRSMN1; SMN2RAB9AL3MBTL1MAPT | |
| SCHEMBL1555274 | 0.77 | SMN1; SMN2 (0.55) | SLC6A3TSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL8409673 | 0.76 | MGLL (0.47) | TSHRLMNASMN1; SMN2RAB9AMAPT | |
| SCHEMBL2094692 | 0.75 | IRAK4 (0.72) | ADRA2AADRA2BADRA2CTSHRIRAK4 | |
| SCHEMBL29523814 | 0.75 | LTB4R (0.57) | TSHRSMN1; SMN2RAB9AL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |