SCHEMBL14967378

SCHEMBL14967378

CCCOC(=O)C1(c2ccc(C)cc2)OC12CCCC2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
OPRM1 P35372 1/20 0.40
TSHR P16473 2/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
PRCP P42785 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
POLB P06746 1/20 0.36
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
ALOX15 P16050 1/20 0.35
CYP2C19 P33261 1/20 0.35
CHRM2 P08172 1/20 0.35
CHRM1 P11229 1/20 0.35
APOBEC3A P31941 1/20 0.34
APOBEC3G Q9HC16 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14967561 0.99 ALDH1A1 (0.41) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967956 0.97 OPRM1 (0.40) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967644 0.92 KMT2A (0.43) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967380 0.91 MEN1 (0.40) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14968056 0.91 KMT2A (0.42) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967712 0.91 OPRM1 (0.49) ALDH1A1MAPTSMN1; SMN2OPRM1MEN1
SCHEMBL14967811 0.90 MEN1 (0.39) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967924 0.90 MEN1 (0.39) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14967982 0.90 KMT2A (0.40) ALDH1A1MAPTSMN1; SMN2OPRM1TSHR
SCHEMBL14968304 0.89 OPRM1 (0.48) ALDH1A1MAPTSMN1; SMN2OPRM1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US claimed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US claimed
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP disclosed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO disclosed