SCHEMBL14967783

SCHEMBL14967783

COc1ccc(C2(C(=O)OC(C)C)OC23CCCC3)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.46
SLC6A3 Q01959 2/20 0.46
HPGD P15428 3/20 0.43
CYP2C19 P33261 2/20 0.43
CYP2C9 P11712 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
RAB9A P51151 1/20 0.43
KDM4E B2RXH2 5/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 3/20 0.43
CYP3A4 P08684 1/20 0.41
LMNA P02545 2/20 0.41
KMT2A Q03164 2/20 0.38
GAA P10253 1/20 0.38
POLB P06746 2/20 0.38
MAPK1 P28482 1/20 0.38
GRIN1 Q05586 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14967683 0.99 SLC6A4 (0.48) SLC6A4SLC6A3HPGDCYP2C19CYP2C9
SCHEMBL14967675 0.97 HPGD (0.43) SLC6A4SLC6A3HPGDCYP2C19CYP2C9
SCHEMBL14968196 0.88 ABHD10 (0.37) HPGDCYP2C19CYP2C9SMN1; SMN2KDM4E
SCHEMBL14968058 0.86 ABHD10 (0.36) SLC6A4SLC6A3HPGDSMN1; SMN2KDM4E
SCHEMBL14967509 0.86 KDM4E (0.46) SLC6A4SLC6A3HPGDCYP2C19CYP2C9
SCHEMBL14967801 0.85 ABHD10 (0.37) HPGDCYP2C19CYP2C9SMN1; SMN2KDM4E
SCHEMBL14967750 0.85 SLC6A4 (0.46) SLC6A4SLC6A3HPGDCYP2C19SMN1; SMN2
SCHEMBL14967459 0.85 APOBEC3A (0.45) SMN1; SMN2NPC1RAB9AALDH1A1LMNA
SCHEMBL14967392 0.84 APOBEC3A (0.44) SLC6A4SLC6A3SMN1; SMN2ALDH1A1MAPK1
SCHEMBL14968066 0.83 ALDH1A1 (0.43) SLC6A4SLC6A3HPGDCYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US claimed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US claimed
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP disclosed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO disclosed