Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969247 | 0.87 | CYP11B1 (0.38) | MAPTPOLBALDH1A1ERN1RAB9A | |
| SCHEMBL14969248 | 0.87 | CYP11B1 (0.38) | MAPTPOLBALDH1A1ERN1RAB9A | |
| SCHEMBL15055254 | 0.81 | DGAT1 (0.49) | MAPTPOLBTP53ALDH1A1TDP1 | |
| SCHEMBL15055252 | 0.81 | DGAT1 (0.49) | MAPTPOLBTP53ALDH1A1TDP1 | |
| SCHEMBL14969514 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1ERN1FFAR4KDM4E | |
| SCHEMBL14969513 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1ERN1FFAR4KDM4E | |
| SCHEMBL14967451 | 0.80 | GRIN2B (0.41) | ERN1FFAR4GRIN2B | |
| SCHEMBL14971854 | 0.79 | ERN1 (0.38) | POLBERN1GRIN2B | |
| SCHEMBL14969203 | 0.79 | ALDH1A1 (0.45) | MAPTALDH1A1RAB9AKDM4ENPC1 | |
| SCHEMBL14968064 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1ERN1FFAR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074387-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2013-05-23 | — | — | WO | disclosed |