SCHEMBL1496843

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496862	0.92	HTR5A (0.40)	KMT2AMEN1HDAC3HDAC1HDAC2
	SCHEMBL1497000	0.92	CYP3A4 (0.39)	KMT2AMEN1HDAC3HDAC1HDAC2
	SCHEMBL1496860	0.92	ROCK2 (0.38)	KMT2AHDAC3HDAC1HDAC2RAF1
	SCHEMBL1497043	0.90	HIF1A (0.42)	HDAC1ROCK2
	SCHEMBL12831883	0.89	RAF1 (0.37)	HDAC1HTTRAF1MAPTCNR1
	SCHEMBL1497447	0.89	HDAC1 (0.35)	HDAC3HDAC1HDAC2NCOR2RAF1
	SCHEMBL1496875	0.88	HTR5A (0.39)	KMT2AMEN1HDAC3HDAC1HDAC2
	SCHEMBL1496893	0.88	POLB (0.37)	HDAC1RAF1MAPTSMN1; SMN2CNR1
	SCHEMBL1496892	0.88	CTSK (0.38)	KMT2AMEN1HDAC3HDAC1HDAC2
	SCHEMBL8001655	0.87	HDAC1 (0.43)	KMT2AMEN1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.