SCHEMBL1496864

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496834	0.95	ROCK2 (0.46)	ROCK2GAAMAPTXBP1SMN1; SMN2
	SCHEMBL3225995	0.94	ROCK2 (0.44)	ROCK2GAAMAPTXBP1SMN1; SMN2
	SCHEMBL3230241	0.92	ROCK2 (0.43)	ROCK2GAAMAPTXBP1SMN1; SMN2
	SCHEMBL1496842	0.92	KMT2A (0.40)	ROCK2MAPTSMN1; SMN2NPSR1ROCK1
	SCHEMBL3262049	0.92	ROCK2 (0.42)	ROCK2GAAMAPTXBP1SMN1; SMN2
	SCHEMBL1496977	0.90	ROCK2 (0.40)	ROCK2GAASMN1; SMN2ROCK1HDAC1
	SCHEMBL3230597	0.89	ROCK2 (0.47)	ROCK2GAAMAPTXBP1SMN1; SMN2
	SCHEMBL11892993	0.88	ROCK2 (0.39)	ROCK2ROCK1HDAC1HDAC6MITF
	SCHEMBL3219418	0.88	HDAC1 (0.42)	ROCK2ROCK1HDAC1HDAC6KCNQ4
	SCHEMBL1496858	0.88	MEN1 (0.41)	ROCK2MAPTSMN1; SMN2ROCK1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.