SCHEMBL1496977

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496829	0.95	ROCK2 (0.43)	ROCK2P2RX3GAARAB9ANPC1
	SCHEMBL3231767	0.93	ROCK2 (0.41)	ROCK2P2RX3KDM4EGAARAB9A
	SCHEMBL1496864	0.90	ROCK2 (0.43)	ROCK2KDM4EGAASMN1; SMN2ROCK1
	SCHEMBL11892993	0.90	ROCK2 (0.39)	ROCK2P2RX3KDM4ERAB9AROCK1
	SCHEMBL1497449	0.89	ROCK2 (0.42)	ROCK2P2RX3GAARAB9ANPC1
	SCHEMBL1496842	0.89	KMT2A (0.40)	ROCK2KDM4ERAB9ASMN1; SMN2ROCK1
	SCHEMBL1496833	0.88	HDAC1 (0.38)	ROCK2P2RX3RAB9AROCK1HDAC1
	SCHEMBL4223993	0.87	ROCK2 (0.40)	ROCK2P2RX3KDM4EGAARAB9A
	SCHEMBL4224494	0.87	ROCK2 (0.40)	ROCK2P2RX3KDM4EGAARAB9A
	SCHEMBL1496841	0.87	RAB9A (0.39)	ROCK2KDM4EGAARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.