SCHEMBL1496904

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1497000	0.92	CYP3A4 (0.39)	ROCK2ROCK1CDC42BPACYP3A4CYP2D6
	SCHEMBL1497029	0.90	ROCK2 (0.42)	ROCK2ROCK1
	SCHEMBL1496967	0.90	HTR5A (0.40)	ROCK2ROCK1ALDH1A1KDM4EHPGD
	SCHEMBL1496853	0.90	ROCK2 (0.49)	ROCK2ROCK1CDC42BPACYP3A4CYP2D6
	SCHEMBL1497063	0.88	ROCK2 (0.46)	ROCK2ROCK1CDC42BPACYP3A4CYP2D6
	SCHEMBL1496972	0.87	NAMPT (0.42)	ROCK2ROCK1CYP3A4ALDH1A1HPGD
	SCHEMBL1497071	0.86	ROCK2 (0.39)	ROCK2ROCK1
	SCHEMBL1497106	0.86	ROCK1 (0.38)	ROCK2ROCK1SMN1; SMN2
	SCHEMBL1496962	0.86	POLB (0.40)	CYP3A4CYP2C9ALDH1A1HTT
	SCHEMBL1496843	0.86	KMT2A (0.40)	ROCK2ROCK1CYP3A4CYP2C9HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.