Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779741 | 0.74 | ADRA1A (0.39) | TP53TSHRADRA2AADRA1ACYP11B1 | |
| SCHEMBL9531758 | 0.68 | TSHR (0.40) | TP53TSHRADRA2AADRA1A | |
| SCHEMBL768819 | 0.67 | MAP3K14 (0.40) | TP53TSHRADRA2AADRA1A | |
| SCHEMBL29829305 | 0.65 | CES2 (0.48) | TP53 | |
| SCHEMBL768915 | 0.63 | TSHR (0.40) | TP53TSHR | |
| SCHEMBL8664825 | 0.63 | RARB (0.39) | TP53TSHR | |
| SCHEMBL769256 | 0.62 | MAP3K14 (0.41) | TP53TSHRADRA2AADRA1A | |
| SCHEMBL769157 | 0.62 | TSHR (0.40) | TP53TSHRADRA2AADRA1A | |
| SCHEMBL20232405 | 0.62 | ALDH1A1 (0.32) | — | |
| SCHEMBL9734357 | 0.62 | KDM5A (0.34) | TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780008-B1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9173404-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9125407-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20150011601-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2015-01-08 | — | — | US | disclosed |
| US-20140303220-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2014-10-09 | — | — | US | disclosed |
| EP-2780008-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | Merial Limited (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074892-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303220-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | TYR, AADAC, PIR | TP53 2807/4885TSHR 3870/4885CASR 4421/4885 |
| US-20150011601-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | TYR, AADAC, PIR | TP53 2807/4885TSHR 3870/4885CASR 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.