Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6009308 | 0.83 | ALDH1A1 (0.46) | ALDH1A1PKML3MBTL1FDPSLMNA | |
| SCHEMBL30845136 | 0.82 | FDPS (0.42) | ALDH1A1PKMFDPSLMNAMAPT | |
| SCHEMBL175216 | 0.77 | FDPS (0.43) | ALDH1A1PKMFDPSTRPM8 | |
| SCHEMBL28853085 | 0.76 | TDP1 (0.51) | ALDH1A1PKML3MBTL1LMNARAB9A | |
| SCHEMBL28330940 | 0.76 | L3MBTL1 (0.39) | ALDH1A1PKML3MBTL1FDPSLMNA | |
| Hydrochloric Acid SCHEMBL31146299 | 0.75 | FDPS (0.42) | ALDH1A1PKMFDPSMEN1KMT2A | |
| SCHEMBL13739398 | 0.74 | RBBP9 (0.48) | ALDH1A1PKMHTTMEN1KMT2A | |
| SCHEMBL2657137 | 0.74 | PLA2G4A (0.44) | ALDH1A1PKML3MBTL1FDPSSMN1; SMN2 | |
| SCHEMBL28540835 | 0.72 | LMNA (0.38) | L3MBTL1LMNAMAPTGAAKMT2A | |
| SCHEMBL6547517 | 0.72 | FDPS (0.51) | ALDH1A1PKMFDPSRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072813-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2013-05-23 | — | — | WO | disclosed |