Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16209378 | 1.00 | KDM4E (0.56) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16218981 | 0.89 | KDM4E (0.43) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16209393 | 0.87 | KDM4E (0.44) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14965915 | 0.87 | KDM4E (0.44) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16218983 | 0.82 | KDM4E (0.39) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16218982 | 0.81 | CNR2 (0.38) | KDM4EHPGDSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14965696 | 0.80 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1KMT2ATSHR | |
| SCHEMBL16209717 | 0.80 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1KMT2ATSHR | |
| SCHEMBL14965971 | 0.78 | CYP3A4 (0.41) | KDM4EALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL16209422 | 0.78 | CYP3A4 (0.41) | KDM4EALDH1A1KMT2APOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073887-B2 | Single step enantioselective process for the preparation of 3-substituted chiral phthalides | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-07-07 | — | — | US | claimed |
| US-20140330027-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-06 | — | — | US | claimed |
| US-20200239460-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2020-07-30 | — | — | US | disclosed |
| US-10450308-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2019-10-22 | — | — | US | disclosed |
| EP-3173411-B1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2018-05-09 | — | — | EP | disclosed |
| US-20170183337-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA L.P. | 2017-06-29 | — | — | US | disclosed |
| EP-3173411-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | Purdue Pharma L.P. (US) | 2017-05-31 | — | — | EP | disclosed |
| US-9630959-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2017-04-25 | — | — | US | disclosed |
| EP-2723732-B1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2017-01-18 | — | — | EP | disclosed |
| US-9505733-B2 | Single step enantioselective process for the preparation of 3-substituted chiral phthalides | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-11-29 | — | — | US | disclosed |
| US-9505733-B2 | Single step enantioselective process for the preparation of 3-substituted chiral phthalides | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-11-29 | — | — | US | disclosed |
| US-9273043-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | PURDUE PHARMA L.P. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150299154-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-10-22 | — | — | US | disclosed |
| US-20150299154-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-10-22 | — | — | US | disclosed |
| US-9073887-B2 | Single step enantioselective process for the preparation of 3-substituted chiral phthalides | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-07-07 | — | — | US | disclosed |
| US-9073887-B2 | Single step enantioselective process for the preparation of 3-substituted chiral phthalides | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-07-07 | — | — | US | disclosed |
| US-20140330027-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-06 | — | — | US | disclosed |
| US-20140330027-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-11-06 | — | — | US | disclosed |
| US-20140329829-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2014-11-06 | — | — | US | disclosed |
| WO-2013072830-A1 | A SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239460-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | TRPV1, TRPA1, TRPV3 | KDM4E 3574/4885HPGD 561/4885SMN1; SMN2 3528/4885 |
| US-20170183337-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | TRPV1, TRPA1, TRPV3 | KDM4E 3574/4885HPGD 561/4885SMN1; SMN2 3528/4885 |
| US-20140330027-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | PPOX, NFE2L2, CBR1 | KDM4E 805/4885HPGD 2135/4885SMN1; SMN2 3151/4885 |
| US-20150299154-A1 | SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES | PPOX, NFE2L2, CBR1 | KDM4E 805/4885HPGD 2135/4885SMN1; SMN2 3151/4885 |
| US-20140329829-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | TRPV1, TRPA1, TRPV3 | KDM4E 3574/4885HPGD 561/4885SMN1; SMN2 3528/4885 |
| US-10450308-B2 | TRPV1 antagonists including dihydroxy substituent and uses thereof | TRPV1, TRPA1, TRPV3 | KDM4E 3574/4885HPGD 561/4885SMN1; SMN2 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.