Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 8/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14971139 | 0.90 | LMNA (0.38) | MITFLMNAPKM | |
| SCHEMBL14971131 | 0.84 | MITF (0.35) | MITFHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14971137 | 0.84 | NR1H3 (0.38) | NR1D1NR1H3MITFLMNA | |
| SCHEMBL14971154 | 0.84 | MITF (0.34) | MITFLMNA | |
| SCHEMBL14971141 | 0.84 | NR1D1 (0.37) | NR1D1NR1H3MITFLMNA | |
| SCHEMBL14971143 | 0.84 | NR1D1 (0.35) | NR1D1KCNA5MITFKCNJ5KCNJ3 | |
| SCHEMBL14971074 | 0.83 | SLC6A9 (0.38) | — | |
| SCHEMBL14971075 | 0.82 | MEP1B (0.38) | MITFLMNA | |
| SCHEMBL14965734 | 0.82 | NR1D1 (0.38) | NR1D1NR1H3KCNA5MITFKCNJ5 | |
| SCHEMBL14971142 | 0.82 | KCNH2 (0.39) | KCNA5MITFKCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |