Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276765 | 0.74 | PARP1 (0.69) | PARP1TP53NTRK1NTRK3ALDH1A1 | |
| SCHEMBL29673205 | 0.73 | PARP1 (1.00) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL1133601 | 0.73 | PARP1 (1.00) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL38236 | 0.66 | KDM4E (0.48) | PARP1CDC7GSK3BALDH1A1KDM4E | |
| SCHEMBL30902522 | 0.66 | TP53 (1.00) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL14361434 | 0.66 | PARP1 (0.60) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL30809703 | 0.66 | PDE2A (0.67) | PARP1TP53POLBGRIN2DGRIN3B | |
| SCHEMBL9415441 | 0.66 | PARP1 (0.60) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL22046017 | 0.66 | TP53 (0.77) | PARP1TP53MAP4K4TAOK1CDC7 | |
| SCHEMBL8566230 | 0.66 | PDE2A (0.67) | PARP1TP53POLBGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576536-B1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | UNIV QUEENSLAND (AU) | 2016-09-14 | — | — | EP | disclosed |
| US-9199976-B2 | Haematopoietic-prostaglandin D2 synthase inhibitors | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-12-01 | — | — | US | disclosed |
| US-20130137684-A1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137684-A1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | HPGDS, PTGES, PTGIS | PARP1 1089/4885TP53 2786/4885MAP4K4 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.