Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669655 | 0.79 | KCNH2 (0.38) | HTR2ATAAR1KIF11ESR1ALDH1A1 | |
| SCHEMBL669373 | 0.79 | KCNH2 (0.38) | HTR2ATAAR1KIF11ESR1ALDH1A1 | |
| SCHEMBL14984858 | 0.79 | KCNH2 (0.38) | HTR2ATAAR1KIF11ESR1ALDH1A1 | |
| SCHEMBL14974361 | 0.79 | KCNH2 (0.38) | HTR2ATAAR1KIF11ESR1ALDH1A1 | |
| SCHEMBL669656 | 0.77 | HTR2A (0.36) | HTR2ATAAR1KIF11ALDH1A1AOC3 | |
| SCHEMBL14987837 | 0.74 | HTR2A (0.37) | HTR2ATAAR1KIF11ESR1ALDH1A1 | |
| SCHEMBL17750791 | 0.74 | CYP2D6 (0.40) | HTR2ATAAR1KIF11ALDH1A1AOC3 | |
| SCHEMBL22454446 | 0.74 | CYP2D6 (0.40) | HTR2ATAAR1KIF11ALDH1A1AOC3 | |
| SCHEMBL755809 | 0.74 | KCNH2 (0.46) | HTR2AALDH1A1MTNR1AMTNR1BAOC3 | |
| SCHEMBL14516176 | 0.74 | KCNH2 (0.46) | HTR2AALDH1A1MTNR1AMTNR1BAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853456-B2 | Process for the preparation of tapentadol | INDOCO REMEDIES LIMITED (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130137890-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | INDOCO REMEDIES LIMITED (IN) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137890-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL | OPRD1, OPRM1, OPRK1 | HTR2A 309/4885TAAR1 18/4885KIF11 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.