Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679440 | 0.98 | LMNA (0.42) | LMNANOS3NOS2KCNN4TAAR1 | |
| Water SCHEMBL11129302 | 0.96 | LMNA (0.41) | LMNANOS3NOS2KCNN4TAAR1 | |
| SCHEMBL4592902 | 0.82 | LMNA (0.42) | LMNANOS3NOS2KCNN4TAAR1 | |
| Bromide SCHEMBL5085160 | 0.80 | HTR2A (0.41) | HTR2A | |
| Bromide SCHEMBL5087833 | 0.80 | HTR2A (0.41) | HTR2A | |
| SCHEMBL11575081 | 0.79 | LMNA (0.44) | LMNANOS3NOS2KCNN4AOC3 | |
| Bromide SCHEMBL6520617 | 0.78 | LMNA (0.42) | LMNANOS3NOS2TAAR1AOC3 | |
| SCHEMBL27433852 | 0.78 | KCNN4 (0.39) | KCNN4TAAR1HTR2A | |
| SCHEMBL7564248 | 0.78 | LMNA (0.45) | LMNANOS3NOS2TAAR1AOC3 | |
| SCHEMBL756292 | 0.78 | LMNA (0.45) | LMNANOS3NOS2KCNN4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999492-A | UV-resistant aging-resistant high-performance LED epoxy resin composition and preparation method thereof | 无锡嘉联电子材料有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999492-A | UV-resistant aging-resistant high-performance LED epoxy resin composition and preparation method thereof | 无锡嘉联电子材料有限公司 | 2022-02-01 | — | — | CN | disclosed |
| US-9593071-B2 | Process for the preparation of gamma amino acids and intermediates used in said process | ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2017-03-14 | — | — | US | disclosed |
| US-20140336412-A1 | PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS | ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2014-11-13 | — | — | US | disclosed |
| EP-2782911-A1 | PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS | Royal College of Surgeons in Ireland (IE) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013076225-A1 | PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS | ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336412-A1 | PROCESS FOR THE PREPARATION OF GAMMA AMINO ACIDS AND INTERMEDIATES USED IN SAID PROCESS | GLRB, GABRP, GABRG1 | LMNA 1563/4885NOS3 2678/4885NOS2 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.