Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 6/20 | 0.38 |
| ▸ | FPR2 | P25090 | 6/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955565 | 0.88 | MMP14 (0.40) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL5955764 | 0.86 | ADAM17 (0.44) | SMN1; SMN2ADAM17ADAMTS5ADAMTS4MMP2 | |
| SCHEMBL29873860 | 0.86 | MMP13 (0.43) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL23367190 | 0.86 | MMP13 (0.43) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL10200265 | 0.81 | EPHX2 (0.35) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL29874400 | 0.80 | CYP3A4 (0.52) | ADAM17ADAMTS5ADAMTS4MMP2MMP13 | |
| SCHEMBL24938581 | 0.80 | CYP3A4 (0.52) | ADAM17ADAMTS5ADAMTS4MMP2MMP13 | |
| SCHEMBL14417733 | 0.77 | ADAM17 (0.43) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL24927725 | 0.77 | ADAMTS7 (0.34) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 | |
| SCHEMBL29979689 | 0.77 | ADAMTS7 (0.34) | ADAM17ADAMTS5ADAMTS4MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976849-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2016-03-09 | — | — | EP | disclosed |
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | TNF, ADAMTS13, MMP11 | NPC1 548/4885RECQL 2945/4885RAB9A 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.