Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 6/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17082355 | 0.86 | DGAT1 (0.41) | LIPEDGAT1ACACBCHRNA7HCRTR1 | |
| SCHEMBL17082348 | 0.86 | CHRNA7 (0.41) | LIPEDGAT1ACACBCHRNA7HCRTR1 | |
| SCHEMBL14979619 | 0.86 | FAAH (0.51) | CYP1A2CYP2C9CYP2C19LIPECHRNA7 | |
| SCHEMBL13691949 | 0.84 | LIPE (0.38) | LIPEDGAT1ACACBCHRNA7HCRTR1 | |
| SCHEMBL518294 | 0.84 | FAAH (0.46) | CYP1A2CYP2C19 | |
| SCHEMBL14979623 | 0.80 | FAAH (0.57) | CYP1A2CYP2C9CYP2C19LIPEGPR119 | |
| SCHEMBL15525341 | 0.80 | DGAT1 (0.57) | DGAT1PIK3CDGPR119 | |
| SCHEMBL31401120 | 0.80 | DGAT1 (0.57) | DGAT1PIK3CDGPR119 | |
| SCHEMBL17082354 | 0.73 | FAAH (0.49) | LIPEGPR119MCHR1BCHE | |
| SCHEMBL15646947 | 0.72 | DGAT1 (0.42) | DGAT1ACACBHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450346-B2 | Azetidine derivatives as FAAH inhibitors | VERNALIS (R&D) LTD. (GB) | 2013-05-28 | — | — | US | disclosed |