Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992719 | 0.87 | MAPK1 (0.46) | EPAS1CRHBPCRHR2MAPTL3MBTL1 | |
| SCHEMBL15053342 | 0.84 | TSHR (0.38) | MAPTL3MBTL1PDE7AALDH1A1LMNA | |
| SCHEMBL15053345 | 0.84 | TSHR (0.38) | MAPTL3MBTL1PDE7AALDH1A1LMNA | |
| SCHEMBL14992106 | 0.84 | CCR2 (0.43) | EPAS1CRHBPCRHR2MAPTL3MBTL1 | |
| SCHEMBL14993373 | 0.77 | TSHR (0.47) | EPAS1MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL15052689 | 0.77 | TSHR (0.47) | EPAS1MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL31364955 | 0.74 | TSHR (0.40) | EPAS1CRHBPCRHR2MAPTL3MBTL1 | |
| SCHEMBL9016031 | 0.73 | MAPT (0.50) | EPAS1CRHBPCRHR2MAPTL3MBTL1 | |
| SCHEMBL23536629 | 0.72 | ALDH1A1 (0.55) | CRHBPCRHR2MAPTPHGDHKDM4E | |
| SCHEMBL3049997 | 0.72 | CRHBP (0.71) | CRHBPCRHR2MAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785710-A1 | SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS | ChemoCentryx, Inc. (US) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013082429-A1 | SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2013-06-06 | — | — | WO | disclosed |