Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ap18 5 SCHEMBL29357634 | 1.00 | TRPA1 (1.00) | TRPA1CYP2C9SIGMAR1ABCB11HDAC3 | |
| Ap18 5 SCHEMBL1962033 | 1.00 | TRPA1 (1.00) | TRPA1CYP2C9SIGMAR1ABCB11HDAC3 | |
| Ap18 5 SCHEMBL12552586 | 1.00 | TRPA1 (1.00) | TRPA1CYP2C9SIGMAR1ABCB11HDAC3 | |
| Ap18 5 SCHEMBL1499542 | 1.00 | TRPA1 (1.00) | TRPA1CYP2C9SIGMAR1ABCB11HDAC3 | |
| SCHEMBL11767293 | 0.81 | TRPA1 (0.68) | TRPA1CYP2C9SIGMAR1ABCB11HDAC3 | |
| SCHEMBL28252409 | 0.79 | TRPA1 (0.66) | TRPA1CYP2C9SIGMAR1ABCB11FBP1 | |
| SCHEMBL3668616 | 0.76 | TRPA1 (0.61) | TRPA1SIGMAR1ABCB11 | |
| SCHEMBL3668618 | 0.76 | TRPA1 (0.61) | TRPA1SIGMAR1ABCB11 | |
| SCHEMBL22995639 | 0.75 | TRPA1 (0.60) | TRPA1CYP2C9HDAC3HDAC4HDAC1 | |
| SCHEMBL22995643 | 0.75 | TRPA1 (0.60) | TRPA1CYP2C9HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108905-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2015-08-18 | — | — | US | claimed |
| US-20110151018-A1 | METHODS OF INSECT CONTROL | BRANDEIS UNIVERSITY (US) | 2011-06-23 | — | — | US | claimed |
| JP-2011509260-A | — | — | 2011-03-24 | — | — | JP | claimed |
| EP-2249820-A1 | TRPA1 ANTAGONISTS | Abbott Laboratories (US) | 2010-11-17 | — | — | EP | claimed |
| WO-2009152261-A1 | METHODS OF INSECT CONTROL BY INHIBITING OR MODULATING THE TRPA1 ION GATED CHANNEL OR FAMILY MEMBERS | BRANDEIS UNIVERSITY (US) | 2009-12-17 | — | — | WO | claimed |
| WO-2009089082-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-07-16 | — | — | WO | claimed |
| US-20090175882-A1 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC (BM) | 2009-07-09 | — | — | US | claimed |
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | claimed |
| EP-1986628-A2 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC A Delware Limited Liability Company (BM) | 2008-11-05 | — | — | EP | claimed |
| WO-2007098252-A2 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC (BM) | 2007-08-30 | — | — | WO | claimed |
| US-9108905-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20110151018-A1 | METHODS OF INSECT CONTROL | BRANDEIS UNIVERSITY (US) | 2011-06-23 | — | — | US | disclosed |
| EP-2249820-A1 | TRPA1 ANTAGONISTS | Abbott Laboratories (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009152261-A1 | METHODS OF INSECT CONTROL BY INHIBITING OR MODULATING THE TRPA1 ION GATED CHANNEL OR FAMILY MEMBERS | BRANDEIS UNIVERSITY (US) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009089082-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-07-16 | — | — | WO | disclosed |
| US-20090175882-A1 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC (BM) | 2009-07-09 | — | — | US | disclosed |
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | disclosed |
| EP-1986628-A2 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC A Delware Limited Liability Company (BM) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098252-A2 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA | IRM LLC (BM) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176883-A1 | TRPA1 Antagonists | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885CYP2C9 2036/4885SIGMAR1 303/4885 |
| US-20110151018-A1 | METHODS OF INSECT CONTROL | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885CYP2C9 2426/4885SIGMAR1 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.